Joshua Wythe, PhD

I joined the faculty in the Department of Molecular Physiology & Biophysics in September 2014 as part of a recruitment effort through the Cardiovascular Research Institute at Baylor College of Medicine.

Before coming to BCM I was at the Gladstone Institute of Cardiovascular Disease at UCSF as a Staff Scientist (2012-2014) and Research Scientist (2011-2012), after being awarded a Scientist Development Grant from the American Heart Association to pursue a project on the transcriptional regulation of endothelial differentiation that I began during my postdoc (with the unflagging encouragement of my mentor!) in Benoit Bruneau's lab.

Prior to that I completed my postdoctoral work in the Bruneau lab where I studied the transcriptional and post-transcriptional regulation of cardiovascular development and disease, with a particular focus on Tbx5 and cardiac lineages, microRNAs, and Slit-Robo signaling.

I credit my graduate advisor at the University of Utah, Dean Y. Li (now Senior Vice President of Discovery Biology and Translational Medicine at Merck Research Labs), and an awesome postdoc in his lab who took me under her wing, Lisa D. Urness, for my interest in cardiovascular development and disease.  My graduate work focused on Elastin signaling in smooth muscle cells, Slit/Robo-mediated regulation of angiogenesis, and the molecular regulation of cardiac contraction in zebrafish-which wouldn't have been possible without the amazingly strong developmental biology program at the U of U (particularly the Grunwald, as well as Yost and late Chi-Bin Chien, laboratories) and our collaborator at Mass General, Calum MacRae (now at the Brigham and Women's Hospital).