Gabrielle Largoza, B.Sc.

I joined the Wythe Lab after receiving my bachelor’s degree in neuroscience from Trinity University in San Antonio, Texas. While completing my undergraduate studies, I was able to conduct research on the effects of inflammation modulation on the intestinal epithelial tight junction complex in Dr. Jonathan King’s laboratory. Throughout my time in Dr. King’s laboratory, I was able to present at numerous conferences and was a recipient of Experimental Biology’s Gastrointestinal & Liver Physiology Section Trainee and Junior Faculty Research Recognition Award.

During my undergraduate career, I was also able to conduct research with Dr. Kathryn Hamilton as an Undergraduate Student Scholar at the University of Pennsylvania. Here, through the lab’s partnership with the Children’s Hospital of Philadelphia, I was able to establish patient-derived 3D intestinal organoids and use them as models for studying pediatric inflammatory bowel disease.

In the Wythe lab my work as a technician focused on understanding the epigenetic and transcriptional regulation of endothelial cell heterogeneity (Gutierrez et al). In the summer of 2023 I moved from Houston to Charlottesville to establish the Wythe Lab at The University of Virginia School of Medicine, where I later enrolled as a graduate student in the Fall of 2024 through the UVA BIMS graduate program. After rotating in the laboratories of Drs. Brant E Isakson, Ken Walsh, and Josh Wythe, I decided to join Josh’s lab to pursue my thesis work on KRAS-driven brain arteriovenous malformations.