FEATURED PUBLICATIONS
For a complete list of publications, please click here.
MEK signaling represents a viable therapeutic vulnerability of KRAS-driven somatic brain arteriovenous malformations
Carlos Flores Suarez, Omar Ashraf Harb, Ariadna Robledo, Gabrielle Largoza, John J. Ahn, Emily K. Alley, Ting Wu, Surabi Veeraragavan, Samuel T. McClugage III, Ionela Iacobas, Jason E Fish, Peter T. Kan, Sean P. Marrelli, Joshua D Wythe
BiorXIV
Protocol for optical, aqueous clearing of murine tissues using EZ Clear
Taeyong Ahn, Gabrielle Largoza, Julia Younis, RE-JOIN Consortium, Mary E. Dickinson, Chih-Wei Hsu, Joshua D. Wythe
STAR Protocols
PMID: 38704833
GPU-Accelerated RSF Level Set Evolution for Large-Scale Microvascular Segmentation
Meher Niger, Helya Goharbavang, Taeyong Ahn, Emily K. Alley, Joshua D. Wythe, Guoning Chen, and David Mayerich
arXiv
PMID: 38654761
2023
The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations
Ashley Ricciardelli, Ariadna Robledo, Jason E. Fish. Peter T. Kan, Tajie H. Harris, Joshua D Wythe
Biomedicines, 2023
PMID: 38001877
Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury
Hali Long, Jeffrey D Steimle, Francisco Jose Grisanti Canozo, Jong Hwan Kim, Xiao Li, Yuka Morikawa, Minjun Park, Diwakar Turaga, Iki Adachi, Joshua D Wythe, Md Abul Hassan Samee, James F Martin.
Life Science Alliance, 2023
PMID: 38012001
Single-cell analysis identifies Ifi27l2a as a novel gene regulator of microglial inflammation in the context of aging and stroke.
Gab Seok Kim, Elisabeth Harmon, Manuel Gutierrez, Jessica Stephenson, Anjali Chauhan, Anik Banerjee, Zachary Wise, Andrea Doan, Ting Wu, Juneyoung Lee, Joo Eun Jung, Louise McCullough, Joshua Wythe, Sean Marrelli
Research Square (Preprint), 2023
PMID: 36824976
2022
Computational insights on coronary artery function.
David Mayerich, Joshua D Wythe
Nature Cardiovascular Research, 2022
PMID: 37564924
Development and characterization of a human arteriovenous malformation (AVM)-on-a-chip model.
Kayla Soon, Mengyuan Li, Ruilin Wu, Williamson D Turner, Joshua D Wythe, Jason E Fish, Sara S Nunes
Biomaterials, 2022
PMID: 35999080
EZ Clear for simple, rapid, and robust mouse whole organ clearing.
Chih-Wei Hsu, Juan Cerda, Jason M Kirk, Williamson D Turner, Tara L Rasmussen, Mary E Dickinson, Carlos P Flores Suarez, Joshua D. Wythe
eLife, 2022
PMID: 36218247
Defining the Transcriptional and Epigenetic Basis of Organotypic Endothelial Diversity in the Developing and Adult Mouse
Manuel E Cantu Gutierrez, Matthew C Hill, Gabrielle Largoza, James F Martin, Joshua D Wythe
bioRxiv
RBFOX2 is required for establishing RNA regulatory networks essential for heart development
Verma SK, Deshmukh V, Thatcher K, Belanger KK, Rhyner AM, Meng S, Holcomb RJ, Bressan M, Martin JF, Cooke JP, Wythe JD, Widen SG, Lincoln J, Kuyumcu-Martinez MN.
Nucleic Acids Research, 2022
PMID: 3513768
FOXO1 represses Sprouty2 and Sprouty4 expression in endothelial cells to promote arterial specification and vascular remodeling in the mouse yolk sac
Nanbing Li-Villarreal, Rebecca Lee Yean Wong, Monica D Garcia, Ryan S Udan, Ross A Poche, Tara L Rasmussen, Alexander M Rhyner, Joshua D Wythe, Mary E Dickinson
Development, 2022
PMID: 35297995
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
David Rohde, Katrien Vandoorne, I Lee, Jana Grune, Shuang Zhang, Cameron S McAlpine, Maximilian J Schloss, Ribhu Nayar, Gabriel Courties, Vanessa Frodermann, Gregory Wojtkiewicz, Lisa Honold, Qi Chen, Stephen Schmidt, Yoshiko Iwamoto, Yuan Sun, Sebastian Cremer, Friedrich F Hoyer, Oriol Iborra-Egea, Christian Muñoz-Guijosa, Fei Ji, Bin Zhou, Ralf H Adams, Joshua D Wythe, Juan Hidalgo, Hideto Watanabe, Yookyung Jung, Anja M van der Laan, Jan J Piek, Youmna Kfoury, Pauline A Désogère, Claudio Vinegoni, Partha Dutta, Ruslan I Sadreyev, Peter Caravan, Antoni Bayes-Genis, Peter Libby, David T Scadden, Charles P Lin, Kamila Naxerova, Filip K Swirski, Matthias Nahrendorf.
Nature Cardiovascular Research, 2022
PMID: 35747128
2021
Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions
Shao Y, Bajikar SS, Tirumala HP, Gutierrez MC, Wythe JD, Zoghbi HY.
Genes & Development, 2021
PMID: 33737384
Identification of diverse tumor endothelial cell populations in malignant glioma
Carlson JC^, Cantu Gutierrez M^, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD*, *Deneen B.
^equal contribution, *co-corresponding.
Neuro-Oncology, 2021
PMID: 33367832.
2020
Somatic Gain of KRAS Function in the Endothelium is Sufficient to Cause Vascular Malformations that Require MEK but not PI3K Signaling
Fish JE^, Flores-Suarez CP^, Boudreau E^, Herman AM, Gutierrez MC,..….Cui M, Chen Z, Berman De Ruiz K, Schexnayder TS, Ward CS, Radovanovic I, Wythe JD. ^equal contribution.
Circulation Research, 2020.
PMID: 32552404 PMID: 32552404
S1PR1 Regulates the Quiescence of Lymphatic Vessels by Inhibiting Laminar Shear Stress-dependent VEGF-C Signaling
Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe JD, Mikelis CM, Hla T, Srinivasan RS.
JCI Insight, 2020.
PMID: 32544090.
Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung
Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J.
Developmental Cell, 2020.
PMID: 32059772.
Development of barium-based low viscosity contrast agents for micro CT vascular casting: Application to 3D visualization of the adult mouse cerebrovasculature
Hong SH, Herman AM, Stephenson JM, Wu T, Bahadur AN, Burns AR, Marrelli SP, Wythe JD.
J Neurosci Res. 2020
PMID: 31630455
2019
FishNET: An automated relational database for zebrafish colony management
Cantu Gutierrez A, Cantu Gutierrez M, Rhyner AM, Ruiz OE, Eisenhoffer GT, Wythe JD.
PLoS Biology, 2019.
PMID: 31220074
A cellular atlas of Pitx2-dependent cardiac development
Hill MC, Kadow ZA, Li L, Tran TT, Wythe JD, Martin JF.
Development, 2019. PMID: 31201182.
2018
Perturbations of BMP/TGF-B and VEGF/VEGFR signaling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM)
Wang K, Zhao S, Liu B, Zhang Q, Li Y, Liu J, Shen Y, Ding X, Lin J, Wu Y, Yan Z, Chen J, Li X, Song X, Niu Y, Liu J, Chen W, Ming Y, Du R, Chen C, Long B, Zhang Y, Tong X, Zhang S, Posey JE, Zhang B, Wu Z, Wythe JD, Liu P, Lupski JR, Yang X, Wu N. Journal of Medical Genetics, 2018.
PMID: 30120215
Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development
Xiao Y, Hill MC, Zhang M, Martin TJ, Morikawa Y, Moise AR, Wythe JD, Martin JF. Developmental Cell, 2018.
PMID: 29689192
A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse
Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD.
Biology Open, 2018.
PMID: 29437553
Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S, Rezai Jahromi B, Khyzha N, DiStefano PV, Suutarinen S, Kiehl TR, Mendes Pereira V, Herman AM, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Rauramaa T, Ylä-Herttuala S, Wythe JD, Antonarakis SE, Frösen J, Fish JE, Radovanovic I.
New England Journal of Medicine. 2018; 378(3):250-261.
PMID: 29298116.
2017
Dynamic Regulation Of VEGF-Inducible Genes By An ERK/ERG/P300 Transcriptional Network
Fish JE^, Cantu Gutierrez M^, Dang LT, Khyzha N, Chen Z, Veitch S, Cheng HS, Khor M, Antounians L, Njock MS, Boudreau E, Herman AM, Rhyner AM, Ruiz OE, Eisenhoffer GT, Medina-Rivera A, Wilson MD, Wythe JD.
^equal contribution.
Development. 2017; 144(13):2428-2444.
PMID: 28536097
2016
Yap and Taz play a crucial role in neural crest-derived craniofacial development
Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF.
Development. 2016; 143(3):504-15.
PMID: 26718006
2015
Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition
Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Cautivo KM, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein A.
Nature Communications, 2015; 6:7739.
PMID: 26204127
The molecular regulation of arteriovenous specification and maintenance
Fish JE, Wythe JD.
Developmental Dynamics, 2015; 244(3):391-409.
PMID: 25641373
University of California, San Francisco / Gladstone Institutes
2014
Early patterning and specification of cardiac progenitors in gastrulating mesoderm
Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG.
Elife, 2014.
PMID: 25296024
2013
ETS factors regulate Vegf-dependent arterial specification
Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE.
Developmental Cell, 2013; 26(1):45-58.
PMID: 23830865